Expressive

rs11130222 - CAMKV, RN7SL217P

Magnitude 2.2 · 3 studies on file

Reported associations

  • Genome-wide association study identifies 74 loci associated with educational attainment - Unknown journal (n.d.) · Unknown authors · PubMed 27225129

    ABSTRACT: Summary Educational attainment (EA) is strongly influenced by social and other environmental factors, but genetic factors are also estimated to account for at least 20% of the variation across individuals. We report the results of a genome-wide association study (GWAS) for EA that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication in an independent sample of 111,349 individuals from the UK Biobank. We now identify 74 genome-wide significant loci associated with number of years of schooling completed. Single-nucleotide polymorphisms (SNPs) associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissu

  • Pleiotropic predisposition to Alzheimer's disease and educational attainment: insights from the summary statistics analysis - Unknown journal (n.d.) · Unknown authors · PubMed 34743297

    ABSTRACT: Epidemiological studies report beneficial associations of higher educational attainment (EDU) with Alzheimer's disease (AD). Prior genome-wide association studies (GWAS) also reported variants associated with AD and EDU separately. The analysis of pleiotropic associations with these phenotypes may shed light on EDU-related protection against AD. We performed pleiotropic meta-analyses using Fisher's method and omnibus test applied to summary statistics for single nucleotide polymorphisms (SNPs) associated with AD and EDU in large-scale univariate GWAS at suggestive-effect (5 × 10−8 < p < 0.1) and genome-wide (p ≤ 5 × 10−8) significance levels. We report 53 SNPs that attained p ≤ 5 × 10−8 at least in one of the pleiotropic meta-analyses and were reported in the uni

  • Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151) - Unknown journal (n.d.) · Unknown authors · PubMed 27046643

    ABSTRACT: People's differences in cognitive functions are partly heritable and are associated with important life outcomes. Previous genome-wide association (GWA) studies of cognitive functions have found evidence for polygenic effects yet, to date, there are few replicated genetic associations. Here we use data from the UK Biobank sample to investigate the genetic contributions to variation in tests of three cognitive functions and in educational attainment. GWA analyses were performed for verbal-numerical reasoning (N=36 035), memory (N=112 067), reaction time (N=111 483) and for the attainment of a college or a university degree (N=111 114). We report genome-wide significant single-nucleotide polymorphism (SNP)-based associations in 20 genomic regions, and significant gene-bas

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