Expressive

rs11130216 - RNF123

Magnitude 2.2 · 1 study on file

Reported associations

  • High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941

    ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Excess dietary sodium Moderate

    Sodium restriction is standard management for elevated blood pressure; carries particular benefit for genetically predisposed individuals

    Limit sodium intake to less than 2300 mg per day; consider DASH diet approach

Discuss with your doctor

  • Cardiovascular risk assessment Moderate

    Genetic predisposition to elevated diastolic blood pressure warrants baseline cardiovascular risk evaluation

    Discuss with healthcare provider; may include lipid panel, ECG, or other cardiovascular screening

Exercise

  • Regular aerobic exercise Moderate

    Aerobic exercise reduces blood pressure; particularly beneficial for individuals with genetic predisposition to elevation

    150 minutes of moderate-intensity aerobic activity per week, spread across multiple days

Screening

  • Blood pressure monitoring Moderate

    Genetic variant associated with elevated diastolic blood pressure; regular monitoring identifies hypertension risk early

    Check blood pressure at least annually, more frequently if elevated; track readings over time