rs11130204 - BSN-DT
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to tobacco use disorder High
Variant at rs11130204 increases risk for tobacco dependence; clinician awareness supports targeted prevention and cessation strategies
discuss at next visit, review personal and family tobacco use history
Lifestyle
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tobacco products and nicotine-containing products High
rs11130204 risk allele associates with increased tobacco use disorder susceptibility; carriers have heightened vulnerability to nicotine dependence
avoid all forms including cigarettes, cigars, smokeless tobacco, and vaping products