rs11129295 - EOMES - LINC01980

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis - Unknown journal (n.d.) · Unknown authors · PubMed 21833088

  ABSTRACT: Multiple sclerosis (OMIM 126200) is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals; and systematic attempts to identify linkage in multiplex families have confirmed that variation within the Major Histocompatibility Complex (MHC) exerts the greatest individual effect on risk. Modestly powered Genome-Wide Association Studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that m

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