rs111283466 - RPL19P11 - CDH6

Magnitude 2.2 · 1 study on file

Reported associations

• CDH6 and HAGH protein levels in plasma associate with Alzheimer's disease in APOE ε4 carriers - Unknown journal (n.d.) · Unknown authors · PubMed 32427856

  ABSTRACT: Many Alzheimer's disease (AD) genes including Apolipoprotein E (APOE) are found to be expressed in blood-derived macrophages and thus may alter blood protein levels. We measured 91 neuro-proteins in plasma from 316 participants of the Rotterdam Study (incident AD = 161) using Proximity Extension Ligation assay. We studied the association of plasma proteins with AD in the overall sample and stratified by APOE. Findings from the Rotterdam study were replicated in 186 AD patients of the BioFINDER study. We further evaluated the correlation of these protein biomarkers with total tau (t-tau), phosphorylated tau (p-tau) and amyloid-beta (Aβ) 42 levels in cerebrospinal fluid (CSF) in the Amsterdam Dementia Cohort (N = 441). Finally, we conducted a genome-wide association stud

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