rs11127486 - LINC01875 - TMEM18

Magnitude 2.2 · 1 study on file

Reported associations

• Association of Multiple-trait Polygenic Risk Score with Obesity and Cardiometabolic Diseases in Korean Population - Unknown journal (n.d.) · Unknown authors · PubMed 41206923

  ABSTRACT: Abstract We conducted a comprehensive genetic investigation of obesity in a cohort of 93,673 Korean individuals, categorized by body mass index and waist circumference using Korean-specific and international criteria. To explore the genetic architecture of obesity and its related comorbidities, we performed genome-wide association studies and constructed polygenic risk scores (PRSs) using both conventional single-trait and advanced multiple-trait models, including the PRSsum approach. Our analyses identified genome-wide significant loci and demonstrated their higher heritability for general obesity than for abdominal obesity, and for moderate obesity than for severe obesity. East Asian populations showed stronger genetic correlations between abdominal obesity and obesity-related

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