rs11126811 - CHMP4AP1 - LINC01815

Magnitude 2.2 · 1 study on file

Reported associations

• Genomewide Association Study of Maximum Habitual Alcohol Intake in >140,000 US European- and African-American Veterans Yields Novel Risk Loci - Unknown journal (n.d.) · Unknown authors · PubMed 31151762

  ABSTRACT: BACKGROUND Habitual alcohol use can be an indicator of alcohol dependence, associated with a wide range of serious health problems. METHODS We completed a genomewide association study in 126,936 European-American (EUR) and 17,029 African-American (AFR) subjects in the Veterans Affairs Million Veteran Program (MVP) for a quantitative phenotype based on maximum habitual alcohol consumption ("MaxAlc"). RESULTS ADH1B, on chromosome 4, was the lead locus for both populations: for EUR, rs1229984 (p=4.9 × 10−47); for AFR, rs2066702 (p=2.3 × 10−12). In the EUR, we identified three additional genomewide-significant (GWS) MaxAlc loci: on chromosome 17, rs77804065 (p=1.5 × 10−12), at CRHR1 (corticotropin-releasing hormone receptor 1); the protein product of this gene is involve

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