rs11125855 - PAPOLG

Magnitude 2.0 · 1 study on file

Reported associations

• Multivariate GWAS of Structural Dental Anomalies and Dental Caries in a Multi-Ethnic Cohort - Frontiers in dental medicine (2025) · Alotaibi RN, Howe BJ, Moreno Uribe LM, Ramirez CV, Restrepo C, Deleyiannis FWB, Padilla C, Orioli IM, Buxó CJ, Hecht JT, Wehby GL, Neiswanger K, Murray JC, Shaffer JR, Weinberg SM, Marazita ML · PubMed 36267138

  ABSTRACT: Odontogenesis is a complex process, where disruption can result in dental anomalies and/or increase the risk of developing dental caries. Based on previous studies, certain dental anomalies tend to co-occur in patients, suggesting that these traits may share common genetic and etiological components. The main goal of this study was to implement a multivariate genome-wide association study approach to identify genetic variants shared between correlated structural dental anomalies and dental caries. Our cohort (N = 3,579) was derived from the Pittsburgh Orofacial Clefts Study, where multiple dental traits were assessed in both the unaffected relatives of orofacial cleft (OFC) cases (n = 2,187) and unaffected controls (n = 1,392). We identified four multivariate patterns of correlat

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