rs111236285 - PCDH1 - DELE1
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population - Unknown journal (n.d.) · Unknown authors · PubMed 40465716
ABSTRACT: We addressed the underrepresentation of non-European populations in genome-wide association studies (GWASs) by building HiGenome, a large-scale genetic resource for the Taiwanese Han population. Using a custom genotyping array, we integrated deidentified electronic medical records (2003 to 2021) with genomic data to enable GWASs, phenome-wide association studies, and polygenic risk score (PRS) analysis. Among 413,000 participants, 323,397 passed ancestry and quality control filtering. GWASs covered 1085 traits, focusing on diseases prevalent in Taiwan such as type 2 diabetes, chronic kidney disease, gout, and alcoholic liver damage. PRSs were calculated for 238 traits, with the strongest associations observed in musculoskeletal disorders. Incorporating PRS into clinical practice
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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limit high-purine foods Moderate
High purine intake increases serum uric acid; this variant increases gout susceptibility
reduce organ meats, shellfish, red meat, and anchovies
Lifestyle
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excessive alcohol consumption Moderate
Alcohol inhibits uric acid excretion and increases production; variant predisposes to gout
limit to moderate intake, avoid binge drinking
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maintain adequate daily hydration Moderate
Adequate hydration lowers serum uric acid concentration; variant increases gout risk
drink 2-3 liters water daily or maintain pale urine color
Screening
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gout risk assessment and serum uric acid measurement Moderate
Variant is associated with increased gout risk; early detection enables prevention