rs11122895 - ANAPC1

Magnitude 2.2 · 1 study on file

Reported associations

• Meta-analysis of genome-wide association studies identifies 10 loci influencing allergic sensitization - Unknown journal (n.d.) · Unknown authors · PubMed 23817571

  ABSTRACT: Allergen-specific IgE (allergic sensitization) plays a central role in the pathogenesis of allergic disease. We performed the first large-scale genome wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP from 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association to allergic sensitization from three to 10, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top-SNPs were associated with allergic symptoms in an independent study. Risk variants at these 10 loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Unde

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