rs11121129 - LINC01714

Magnitude 2.2 · 1 study on file

Reported associations

• Identification of fifteen new psoriasis susceptibility loci highlights the role of innate immunity - Unknown journal (n.d.) · Unknown authors · PubMed 23143594

  ABSTRACT: Summary To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of three genome-wide association studies (GWAS) and two independent datasets genotyped on the Immunochip, involving 10,588 cases and 22,806 controls in total. We identified 15 new disease susceptibility regions, increasing the number of psoriasis-associated loci to 36 for Caucasians. Conditional analyses identified five independent signals within previously known loci. The newly identified shared disease regions encompassed a number of genes whose products regulate T-cell function (e.g. RUNX3, TAGAP and STAT3). The new psoriasis-specific regions were notable for candidate genes whose products are involved in innate host defense, encoding proteins with roles in interferon-media

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