rs11120828 - CAMTA1
Magnitude 2.2 · 1 study on file
Reported associations
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GWAS in people of Middle Eastern descent reveals a locus protective of kidney function-a cross-sectional study - Unknown journal (n.d.) · Unknown authors · PubMed 35227251
ABSTRACT: Background Type 2 diabetes is one of the leading causes of chronic kidney failure, which increases globally and represents a significant threat to public health. People from the Middle East represent one of the largest immigrant groups in Europe today. Despite poor glucose regulation and high risk for early-onset insulin-deficient type 2 diabetes, they have better kidney function and lower rates of all-cause and cardiovascular-specific mortality compared with people of European ancestry. Here, we assessed the genetic basis of estimated glomerular filtration rate (eGFR) and other metabolic traits in people of Iraqi ancestry living in southern Sweden. Methods Genome-wide association study (GWAS) analyses were performed in 1201 Iraqi-born residents of the city of Malmö for eGFR and
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic diabetes predisposition Moderate
CAMTA1 rs11120828 variant impairs beta-cell development and insulin secretion; associated with elevated glucose markers in GWAS
Screening
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Fasting glucose levels Moderate
Variant associated with higher fasting glucose (p=1.6e-10); reflects impaired beta-cell function and insulin secretion
Include in annual health assessments
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HbA1c levels Moderate
rs11120828 A allele associated with elevated HbA1c (p=4.4e-11); indicates increased glycemic burden and diabetes risk
Test at least annually, more frequently if elevated