rs11118774 - LINC02817 - DUSP10

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study of varicose veins identifies a protective missense variant in GJD3 enriched in the Finnish population - Unknown journal (n.d.) · Unknown authors · PubMed 36653477

  ABSTRACT: Varicose veins is the most common manifestation of chronic venous disease that displays female-biased incidence. To identify protein-inactivating variants that could guide identification of drug target genes for varicose veins and genetic evidence for the disease prevalence difference between the sexes, we conducted a genome-wide association study of varicose veins in Finns using the FinnGen dataset with 17,027 cases and 190,028 controls. We identified 50 associated genetic loci (P < 5.0 × 10−8) of which 29 were novel including one near ERG with female-specificity (rs2836405-G, OR[95% CI] = 1.09[1.05-1.13], P = 3.1 × 10−8). These also include two X-chromosomal (ARHGAP6 and SRPX) and two autosomal novel loci (TGFB2 and GJD3) with protein-coding lead va

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