rs11118580 - CD46, MIR29B2CHG
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Macular degeneration genetic risk and prevention Moderate
Personalized prevention strategies can be developed with ophthalmologist based on genetic risk
Lifestyle
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Smoking Moderate
Smoking is a major modifiable risk factor for macular degeneration; increased genetic risk makes avoidance critical
Screening
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Macular degeneration risk screening Moderate
CD46 variant increases macular degeneration risk through complement regulatory pathway dysfunction
Annual comprehensive retinal examination and optical coherence tomography