rs11111647 - LINC02401

Magnitude 2.8 · 1 study on file

Reported associations

• Genome-wide association study of susceptibility to acute respiratory distress syndrome - Unknown journal (n.d.) · Unknown authors · PubMed 41033104

  ABSTRACT: Summary Background Acute respiratory distress syndrome (ARDS) is a severe inflammatory process of the lung, often due to sepsis, and poses significant mortality burden in intensive care units. Here we conducted a genome-wide association study (GWAS) of ARDS to identify genetic risk loci that can help guide the development of new therapeutic options. Methods We performed a case-control GWAS in 716 cases with ARDS, mainly associated with severe infections, and 4399 at-risk controls from three independent studies. Results were meta-analysed across the three studies, with significance set at p < 5 × 10−8. Suggestive associations were declared for variants exhibiting consistent direction of effects, likely to replicate and nominal significance (p < 0.05) in all three studies. Pri

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