rs11109072 - RMST

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity - Unknown journal (n.d.) · Unknown authors · PubMed 23563609

  [INTRO] Common and rare variants associated with body mass index (BMI) and obesity account for <5% of the variance in BMI. We performed SNP and CNV association analyses in 1,509 children with obesity at the extreme tail (>3 standard deviations) of the BMI distribution and 5380 controls. Evaluation of 29 SNPs (p<10−5) in an additional 971 severely obese children and 1990 controls identified four new loci associated with severe obesity (LEPR, PRKCH, PACS1, RMST). A previously reported 43kb deletion at the NEGR1 locus was significantly associated with severe obesity (p=6.6×10−7). However, this signal was entirely driven by a flanking 8kb deletion; absence of this deletion increased risk for obesity (p=6.1×10−11). We found a significant burden of rare, single CNVs in severely obese cas

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