rs11105383 - ATP2B1-AS1
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits - Unknown journal (n.d.) · Unknown authors · PubMed 39537608
ABSTRACT: Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic loci associated with both Alzheimer's and cardiovascular diseases. We prioritised rs11786896, which colocalised with Alzheimer's disease, atrial fibrillation and expression of PLEC in the heart left ventricle, and rs7529220, which colocalised with Alzheimer's disease, atrial fibrillation and expression of C1Q family genes. Single-cell RNA-sequencing data, co-expression network and protein-protein interaction analyses provided evidence for different mechanisms of PLEC, which is upregulated in left ventricular endothelium and cardiomyocyte
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Limit dietary sodium intake Moderate
High sodium raises blood pressure; carriers of BP-raising variant may benefit from sodium restriction
Target less than 2,300 mg sodium per day
Exercise
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Regular aerobic exercise for blood pressure management Moderate
Exercise reduces blood pressure; genetic predisposition makes regular activity important
150 minutes per week of moderate-intensity aerobic activity
Screening
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Blood pressure monitoring Moderate
Variant associated with increased diastolic blood pressure in large population study
Check blood pressure annually or as clinically indicated