rs11105368 - ATP2B1
Magnitude 2.8 · 1 study on file
Reported associations
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Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults - Unknown journal (n.d.) · Unknown authors · PubMed 28273873
ABSTRACT: Hypertension is a complex disease explained with diverse factors including environmental factors and genetic factors. The objectives of this study were to determine the interaction effects between gene variants and 24 h estimated urinary sodium and potassium excretion and sodium-potassium excretion ratios on the risk of hypertension. A total of 8839 participants were included in the genome-wide association study (GWAS) to find genetic factors associated with hypertension. Tanaka and Kawasaki formulas were applied to estimate 24 h urinary sodium and potassium excretion. A total of 4414 participants were included in interaction analyses to identify the interaction effects of gene variants according to 24 h estimated urinary factors on the risk of hypertension. CSK rs1378942 and CSK
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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baseline and periodic blood pressure assessment Moderate
ATP2B1 encodes a plasma membrane calcium pump in vascular endothelium; risk alleles reduce calcium extrusion capacity, impairing vascular smooth muscle relaxation
Obtain baseline blood pressure at next clinical visit; discuss screening intervals with physician if risk allele carrier