Expressive

rs11105364 - ATP2B1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-Wide Association Study Meta-Analysis of Long Term Average Blood Pressure in East Asians - Unknown journal (n.d.) · Unknown authors · PubMed 28348047

    ABSTRACT: Background Genome-wide single marker and gene-based meta-analyses of long term average (LTA) blood pressure (BP) phenotypes may reveal novel findings for BP. Methods and Results We conducted genome-wide analysis among 18,422 East Asian participants (stage-1) followed by replication study of up to 46,629 participants of European ancestry (stage-2). Significant SNPs and genes were determined by a P<5.0×10−8 and 2.5×10−6, respectively, in joint analyses of stage-1 and stage-2 data. We identified one novel ARL3 variant, rs4919669 at 10q24.32, influencing LTA systolic BP (stage-1 P=5.03×10−8, stage-2 P=8.64×10−3, joint P=2.63×10−8) and mean arterial pressure (stage-1 P=3.59×10−9, stage-2 P=2.35×10−2, joint P=2.64×10−8). Three previously reported BP loci (WBP1L,

  • Interethnic analyses of blood pressure loci in populations of East Asian and European descent - Unknown journal (n.d.) · Unknown authors · PubMed 30487518

    ABSTRACT: Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Adequate potassium intake Moderate

    Potassium modulates sodium-potassium balance and vascular tone; important for blood pressure regulation in those with genetic BP predisposition

    Consume potassium-rich foods daily; aim for 3000-4000 mg per day

  • Limit dietary sodium intake Moderate

    Dietary sodium restriction effectively lowers blood pressure; particularly relevant given genetic elevation risk from ATP2B1 variant

    Target less than 2300 mg sodium daily

Discuss with your doctor

  • Genetic predisposition to elevated blood pressure and prevention strategy High

    GWAS shows strong genetic association with elevated diastolic blood pressure; doctor can assess individual risk and personalize prevention approach

    Schedule appointment to discuss findings and create management plan

Exercise

  • Regular aerobic exercise Moderate

    Aerobic exercise improves vascular function and reduces blood pressure; particularly important with genetic predisposition to elevated diastolic pressure

    Aim for 150 minutes moderate-intensity aerobic exercise per week

Screening

  • Regular blood pressure measurement High

    ATP2B1 rs11105364 T allele robustly associates with elevated diastolic blood pressure; baseline assessment enables early detection of clinical manifestation

    Obtain baseline BP reading; establish annual screening starting in 20s-30s, more frequent if elevated