Expressive

rs1110494 - LINC01571 - LINC00919

Magnitude 2.2 · 1 study on file

Reported associations

  • An atlas of genetic influences on osteoporosis in humans and mice - Unknown journal (n.d.) · Unknown authors · PubMed 30598549

    ABSTRACT: Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative ultrasound (eBMD) in 426,824 individuals, identifying 518 genome-wide significant loci (301 novel), explaining 20% of its variance. We identified 13 bone fracture loci, all associated with eBMD, in ~1.2M individuals. We then identified target genes enriched for genes known to influence bone density and strength (maximum odds-ratio=58, p=10-75) from cell-specific features, including chromatin conformation and accessible chromatin sites. We next performed rapid-throughput skeletal phenotyping of 126 knockout mice lacking target genes and found an increased abnormal skeletal phenotype frequency compared to 526

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • vitamin D status (25-hydroxyvitamin D) Moderate

    Vitamin D is essential for calcium absorption and bone mineralization; adequate levels support bone density despite genetic predisposition

    Check serum 25-hydroxyvitamin D; maintain levels above 30 ng/mL

Diet

  • adequate dietary calcium intake Moderate

    Calcium is the primary structural component of bone; adequate intake is particularly important given genetic predisposition to lower bone density

    Aim for 1000-1200 mg daily from dietary sources (dairy, leafy greens, fortified foods)

Discuss with your doctor

  • osteoporosis risk assessment and prevention strategy Moderate

    Genetic predisposition to lower bone mineral density increases fracture risk; clinical assessment can guide personalized prevention interventions

Exercise

  • weight-bearing exercise Moderate

    Mechanical loading from weight-bearing activities stimulates bone-forming osteoblasts and increases bone density; particularly important given genetic susceptibility

    150+ minutes per week of moderate-intensity weight-bearing activity (walking, running, resistance training)

Supplements

  • vitamin D supplementation Moderate

    Vitamin D supports calcium absorption and bone mineralization; optimization may particularly benefit those with genetic predisposition to lower bone density

    1000-2000 IU daily, adjusted based on serum 25-hydroxyvitamin D levels