rs11103429 - RXRA - COL5A1

Magnitude 4.5 · 1 study on file

Reported associations

• Multi-dimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease - Unknown journal (n.d.) · Unknown authors · PubMed 23665963

  ABSTRACT: Background The ability to identify patients with Crohn's disease (CD) at highest risk of surgery would be invaluable in guiding therapy. Genome-wide association (GWA) studies have identified multiple IBD loci with unknown phenotypic consequences. Objectives 1) to identify associations between known and novel CD loci with early resective CD surgery2) to develop the best predictive model for time to surgery using a combination of phenotypic, serologic and genetic variables. Methods Genotyping was performed on 1115 subjects using Illumina-based Genome-wide technology. Univariate and multivariate analyses tested genetic associations with need for surgery within 5 years. Analyses were performed by testing known CD loci (n=71) and by performing a GWA study. Time to surgery was analyz

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