rs11101442 - WDFY4

Magnitude 2.0 · 1 study on file

Reported associations

• Genetic Variants Near TNFAIP3 on 6q23 are Associated with Systemic Lupus Erythematosus (SLE) - Unknown journal (n.d.) · Unknown authors · PubMed 19165918

  ABSTRACT: SLE is an autoimmune disease influenced by genetic and environmental components. We performed a genome-wide association scan (GWAS) and observed novel association evidence with a variant inTNFAIP3(rs5029939, P = 2.89×10−12, OR = 2.29). We also found evidence of two independent signals of association to SLE risk, including one described in Rheumatoid Arthritis. These results establish that genetic variation inTNFAIP3contributes to differential risk for SLE and RA. FULL TEXT: [INTRO] Systemic lupus erythematosus (SLE, OMIM 152700) is an autoimmune disease characterized by dysregulated interferon responses and loss of self-tolerance to cellular antigens. Autoantibody production leads to immune complex formation resulting in local and systemic inflammation and organ failure. The

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