rs11099341 - KRT18P54 - TARS2P1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 29317602
ABSTRACT: Few replicable genetic associations for Major Depressive Disorder (MDD) have been identified. Recent studies of MDD have identified common risk variants by using a broader phenotype definition in very large samples, or by reducing phenotypic and ancestral heterogeneity. We sought to ascertain whether it is more informative to maximize the sample size using data from all available cases and controls, or to use a sex or recurrent stratified subset of affected individuals. To test this, we compared heritability estimates, genetic correlation with other traits, variance explained by MDD polygenic score, and variants identified by genome-wide meta-analysis for broad and narrow MDD classifications in two large British cohorts - Generation Scotland and UK Biobank. Genome-wide meta-analy
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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depression risk assessment and monitoring Moderate
Genetic variant associated with increased major depressive disorder susceptibility in large GWAS cohort.
Discuss family history and screening with primary care provider.