rs11099336 - LINC02485 - U6
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827
ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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caloric and macronutrient balance Moderate
T allele at rs11099336 is associated with increased BMI; balanced nutrition supports weight management.
Maintain diet aligned with activity level and weight goals
Exercise
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regular physical activity Moderate
T allele at rs11099336 is associated with increased BMI; regular exercise supports healthy weight management.
150+ minutes of moderate intensity activity per week
Screening
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BMI screening Moderate
T allele at rs11099336 is associated with increased BMI predisposition.
Track BMI at routine health visits, quarterly if available