rs11096913 - TBC1D1

Magnitude 2.8 · 1 study on file

Reported associations

• Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1 - Unknown journal (n.d.) · Unknown authors · PubMed 22959728

  ABSTRACT: Amyotrophic lateral sclerosis (ALS) is the third most common adult-onset neurodegenerative disease. Individuals with ALS rapidly progress to paralysis and die from respiratory failure within 3 to 5 years after symptom onset. Epidemiological factors explain only a modest amount of the risk for ALS. However, there is growing evidence of a strong genetic component to both familial and sporadic ALS risk. The International Consortium on Amyotrophic Lateral Sclerosis Genetics was established to bring together existing genome-wide association cohorts and identify sporadic ALS susceptibility and age at symptom onset loci. Here, we report the results of a meta-analysis of the International Consortium on Amyotrophic Lateral Sclerosis Genetics genome-wide association samples, consisting of

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