rs11087368 - LINC01432
Magnitude 2.2 · 1 study on file
Reported associations
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GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk - Unknown journal (n.d.) · Unknown authors · PubMed 29146897
ABSTRACT: Male pattern baldness (MPB) or androgenetic alopecia is one of the most common conditions affecting men, reaching a prevalence of ~50% by the age of 50; however, the known genes explain little of the heritability. Here, we present the results of a genome-wide association study including more than 70,000 men, identifying 71 independently replicated loci, of which 30 are novel. These loci explain 38% of the risk, suggesting that MPB is less genetically complex than other complex traits. We show that many of these loci contain genes that are relevant to the pathology and highlight pathways and functions underlying baldness. Finally, despite only showing genome-wide genetic correlation with height, pathway-specific genetic correlations are significant for traits including lifespan a
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Management options for genetic male-pattern baldness risk Moderate
High genetic risk from rs11087368 warrants proactive discussion of prevention and management strategies with a healthcare provider.
Discuss with dermatologist or primary care physician
Screening
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Male-pattern baldness monitoring High
Carriers of rs11087368 have substantially elevated genetic risk for androgenetic alopecia; early detection enables timely intervention.
Annual or semi-annual scalp assessments starting in 20s