Expressive

rs11087114 - MACROD2

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide admixture and association study of subclinical atherosclerosis in the Women's Interagency HIV Study (WIHS) - Unknown journal (n.d.) · Unknown authors · PubMed 29206233

    ABSTRACT: Cardiovascular disease (CVD) is a major comorbidity among HIV-infected individuals. Common carotid artery intima-media thickness (cCIMT) is a valid and reliable subclinical measure of atherosclerosis and is known to predict CVD. We performed genome-wide association (GWA) and admixture analysis among 682 HIV-positive and 288 HIV-negative Black, non-Hispanic women from the Women's Interagency HIV study (WIHS) cohort using a combined and stratified analysis approach. We found some suggestive associations but none of the SNPs reached genome-wide statistical significance in our GWAS analysis. The top GWAS SNPs were rs2280828 in the region intergenic to mediator complex subunit 30 and exostosin glycosyltransferase 1 (MED30 | EXT1) among all women, rs2907092 in the catenin delta 2 (CT

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • lipid panel and blood pressure Low

    lipid profile and blood pressure are key modifiable risk factors for atherosclerosis progression

    annual lipid panel and blood pressure checks or more frequently based on baseline values

Diet

  • Mediterranean or DASH diet pattern Low

    anti-inflammatory and antioxidant-rich dietary patterns may slow atherosclerosis progression

    emphasize vegetables, fruits, whole grains, fish, nuts; limit saturated fat

Exercise

  • regular aerobic physical activity Low

    aerobic exercise improves endothelial function and reduces atherosclerosis progression

    at least 150 minutes per week of moderate-intensity aerobic activity

Screening

  • cardiovascular disease risk with imaging or risk assessment Low

    rs11087114 A allele is associated with increased carotid artery intima-media thickness, a subclinical atherosclerosis marker

    discuss timing and modality of cardiovascular screening with healthcare provider