rs1108616 - ZMIZ1
Magnitude 2.2 · 1 study on file
Reported associations
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Genomics and phenomics of body mass index reveals a complex disease network - Unknown journal (n.d.) · Unknown authors · PubMed 36581621
ABSTRACT: Elevated body mass index (BMI) is heritable and associated with many health conditions that impact morbidity and mortality. The study of the genetic association of BMI across a broad range of common disease conditions offers the opportunity to extend current knowledge regarding the breadth and depth of adiposity-related diseases. We identify 906 (364 novel) and 41 (6 novel) genome-wide significant loci for BMI among participants of European (N~1.1 million) and African (N~100,000) ancestry, respectively. Using a BMI genetic risk score including 2446 variants, 316 diagnoses are associated in the Million Veteran Program, with 96.5% showing increased risk. A co-morbidity network analysis reveals seven disease communities containing multiple interconnected diseases associated with BMI
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic BMI risk and preventive strategy Moderate
Carrier status for increased-BMI variant warrants discussion of proactive monitoring and early intervention options.
Lifestyle
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Structured weight management program Moderate
Genetic predisposition to weight gain may benefit from proactive lifestyle modification combining diet and aerobic exercise.
Explore behavioral weight management programs or nutritionist consultation for personalized guidance.
Screening
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BMI and weight trend monitoring Moderate
Genetic variant associated with increased body mass index; earlier detection of weight gain enables timely intervention.
Measure BMI quarterly; chart weight and waist circumference trends to detect changes early.