Expressive

rs11083637 - CEACAM5

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetic modifiers of asthma response to air pollution in children: An African ancestry GWAS and PM polygenic risk score study. - Environmental research (2025) · Kelchtermans J, March ME, Mentch F, Qu H, Liu Y, Nguyen K, Hakonarson H · PubMed 39725137

    Ambient air pollution (AAP) is linked to asthma outcomes, but predicting individual risk remains challenging. Understanding genetic contributors to AAP sensitivity may help overcome this gap. To determine if single nucleotide polymorphisms (SNPs) are associated with AAP sensitivity in children with asthma. We complete a GWAS in pediatric patients with asthma frequently exposed to AAP, comparing patients with exacerbations following spikes in AAP to patients without this temporal association and calculate a polygenic risk score (PRS) for PM . This PRS was validated using internal data and data from the All of Us cohort. We included 6023 patients in the GWAS, restricted to the African ancestry cohort due to the association between AAP exposure and race. Three loci reached genome-wide signifi

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • enhanced asthma action plan for air pollution triggers Moderate

    Genetic predisposition to PM10-triggered exacerbations warrants proactive management strategy

    develop personalized asthma action plan including rescue medication use during high pollution periods

Lifestyle

  • high PM10 pollution exposure during air quality warnings Moderate

    CEACAM variants affect respiratory epithelial adhesion molecules; impaired epithelial barrier function increases susceptibility to particulate matter-induced inflammation

    check air quality daily; limit outdoor activity on high PM10 days (typically PM10 > 150 ug/m3)

Screening

  • respiratory symptoms on high air pollution days Moderate

    This SNP is associated with PM10-induced asthma exacerbations; heightened vigilance enables early intervention

    watch for cough, dyspnea, or wheezing on high PM10 days; keep rescue inhaler accessible during pollution events