rs11079797 - LRRC46

Magnitude 2.2 · 1 study on file

Reported associations

• Clinical effects of novel susceptibility genes for beta-amyloid: a gene-based association study in the Korean population - Unknown journal (n.d.) · Unknown authors · PubMed 37901794

  ABSTRACT: Amyloid-beta (Aβ) is a pathological hallmark of Alzheimer's disease (AD). We aimed to identify genes related to Aβ uptake in the Korean population and investigate the effects of these novel genes on clinical outcomes, including neurodegeneration and cognitive impairments. We recruited a total of 759 Korean participants who underwent neuropsychological tests, brain magnetic resonance imaging, 18F-flutemetamol positron emission tomography, and microarray genotyping data. We performed gene-based association analysis, and also performed expression quantitative trait loci and network analysis. In genome-wide association studies, no single nucleotide polymorphism (SNP) passed the genome-wide significance threshold. In gene-based association analysis, six genes (LCMT1, SCRN2, LRRC46

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