Expressive

rs11079480 - TLK2

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture - Unknown journal (n.d.) · Unknown authors · PubMed 30048462

    ABSTRACT: Low bone mineral density (BMD) leads to osteoporosis, and is a risk factor for bone fractures, including stress fractures. Using data from UK Biobank, a genome-wide association study identified 1,362 independent SNPs that clustered into 899 loci of which 613 are new. These data were used to train a genetic algorithm using 22,886 SNPs as predictors and showing a correlation with heel bone mineral density of 0.415. Combining this genetic algorithm with height, weight, age and sex resulted in a correlation with heel bone mineral density of 0.496. Individuals with low scores (2.2% of total) showed a change in BMD of -1.16 T-score units, an increase in risk for osteoporosis of 17.4 fold and an increase in risk for fracture of 1.87 fold. Genetic predictors could assist in the identific

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • adequate dietary calcium Moderate

    Calcium is essential for bone mineralization; this variant reduces BMD

    Target 1000-1200 mg elemental calcium daily from food; supplement if needed

Exercise

  • weight-bearing and resistance exercise Moderate

    Mechanical loading from weight-bearing and resistance exercise stimulates bone formation and improves density

    150 min/week aerobic weight-bearing activity or 2-3x/week resistance training

Screening

  • bone mineral density assessment Moderate

    This variant associates with reduced heel bone mineral density, a clinical indicator of fracture risk

    DEXA scan at baseline; frequency per clinical guidelines and T-score results

Supplements

  • vitamin D supplementation Moderate

    Vitamin D enables calcium absorption and bone mineralization; supports BMD

    800-1000 IU daily; measure 25-OH vitamin D and adjust to 30-50 ng/mL range