rs11078935 - MED24

Magnitude 2.2 · 1 study on file

Reported associations

• Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance - Unknown journal (n.d.) · Unknown authors · PubMed 33385171

  ABSTRACT: Mitochondrial (MT) dysfunction is a hallmark of aging and has been associated with most aging-related diseases as well as immunological processes. However, little is known about aging, lifestyle and genetic factors influencing mitochondrial DNA (mtDNA) abundance. In this study, mtDNA abundance was estimated from the weighted intensities of probes mapping to the MT genome in 295,150 participants from the UK Biobank. We found that the abundance of mtDNA was significantly elevated in women compared to men, was negatively correlated with advanced age, higher smoking exposure, greater body-mass index, higher frailty index as well as elevated red and white blood cell count and lower mortality. In addition, several biochemistry markers in blood-related to cholesterol metabolism, ion hom

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