rs11078446 - CRK

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population. - Science China. Life sciences (2020) · Huang L, Chen Y, Lin Y, Tam POS, Cheng Y, Shi Y, Gong B, Lu F, Yang J, Wang H, Yin Y, Cao Y, Jiang D, Zhong L, Xue B, Wang J, Hao F, Lee DY, Pang CP, Sun X, Yang Z · PubMed 30591961

  Intraocular pressure (IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10 , and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10 , including 4 previously reported loci: rs145063132 (7p21.2, ETV1/DGKB), rs548030386 (7q31.2, ST7 near CAV1/CAV2), rs7047871 (9p24.2, GLIS3), and rs2472494 (9q31.1, ABCA1/S

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