rs11077601 - LINC00511, LINC02003
Magnitude 2.2 · 1 study on file
Reported associations
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Central Adiposity Increases Risk of Kidney Stone Disease through Effects on Serum Calcium Concentrations - Unknown journal (n.d.) · Unknown authors · PubMed 37787550
ABSTRACT: Visual Abstract Significance Statement Kidney stone disease is a common disorder with poorly understood pathophysiology. Observational and genetic studies indicate that adiposity is associated with an increased risk of kidney stone disease. However, the relative contribution of general and central adipose depots and the mechanisms by which effects of adiposity on kidney stone disease are mediated have not been defined. Using conventional and genetic epidemiological techniques, we demonstrate that general and central adiposity are independently associated with kidney stone disease. In addition, one mechanism by which central adiposity increases risk of kidney stone disease is by increasing serum calcium concentration. Therapies targeting adipose depots may affect calcium homeostas
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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serum and urinary calcium concentrations Moderate
serum calcium mediates the effect of central adiposity on kidney stone risk; hypercalciuria is a major stone formation risk factor
annual serum calcium; consider 24-hour urinary calcium testing if elevated
Diet
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adequate daily hydration Moderate
increased urine dilution reduces urinary crystal saturation and kidney stone formation risk
aim for urine output of 2-3 liters daily
Lifestyle
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reduce central adiposity Moderate
central adiposity causally increases serum calcium concentration and kidney stone formation risk independent of general adiposity
target waist circumference reduction through combined diet and aerobic exercise
Screening
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kidney stone disease screening High
rs11077601 T allele associates with 9% increased kidney stone disease risk; early detection enables preventive treatment
discuss kidney stone screening protocol with primary care doctor