rs11074247 - LINC01581, LINC01579

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic variants and functional pathways associated with resilience to Alzheimer's disease - Unknown journal (n.d.) · Unknown authors · PubMed 32844198

  ABSTRACT: Why are some individuals able to tolerate severe Alzheimer's disease pathology without experiencing dementia? Dumitrescu et al. perform a large genome-wide analysis of resilience to Alzheimer's disease and highlight several biological pathways that may protect the brain from the downstream consequences of amyloidosis. Abstract Approximately 30% of older adults exhibit the neuropathological features of Alzheimer's disease without signs of cognitive impairment. Yet, little is known about the genetic factors that allow these potentially resilient individuals to remain cognitively unimpaired in the face of substantial neuropathology. We performed a large, genome-wide association study (GWAS) of two previously validated metrics of cognitive resilience quantified using a latent v

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