Expressive

rs11074227 - LINC01579

Magnitude 2.2 · 1 study on file

Reported associations

  • Twelve Loci Associated With Bone Density in Middle-aged and Elderly Chinese: The Shanghai Changfeng Study. - The Journal of clinical endocrinology and metabolism (2023) · Zeng H, Ge J, Xu W, Ma H, Chen L, Xia M, Pan B, Lin H, Wang S, Gao X · PubMed 36228083

    Previous genome-wide association studies (GWASs) of bone mineral density (BMD) were mainly conducted in Europeans. To explore genetic variants that affect BMD and sex differences in a Chinese population. A total of 5428 middle-aged and elderly Chinese were included. Dual-energy X-ray absorptiometry was used to measure BMD at the lumbar spine, and total and specific sites of the hip. A mixed linear model was used to analyze the associations between BMD and autosomal genetic variants, adjusting for age, age squared, sex, and menopausal women (model 1); model 2 was further adjusted for height and weight. A GWAS of osteoporosis in the Biobank Japan (BBJ) project was used for replication. GWAMA software was used to detect the statistical significance of sex differences of estimated effects. Gen

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • adequate calcium and vitamin D intake Moderate

    rs11074227 is associated with bone mineral density; calcium and vitamin D are essential for bone formation and maintenance

    Aim for 1000-1200mg calcium and 600-800 IU vitamin D daily; consider testing if deficiency suspected

Exercise

  • weight-bearing exercise for bone strength Moderate

    rs11074227 associates with bone mineral density; weight-bearing exercise supports bone density

    150 minutes per week moderate-intensity weight-bearing activity, or follow physician guidance

Screening

  • bone mineral density (DEXA) screening Moderate

    rs11074227 is associated with proximal femur bone mineral density variation, which affects fracture risk

    Discuss with your physician for baseline assessment and monitoring interval