rs11071625 - RORA - LINC02349

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study of suicidal behaviour severity in mood disorders. - The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2021) · Zai CC, Fabbri C, Hosang GM, Zhang RS, Koyama E, de Luca V, Tiwari AK, King N, Strauss J, Jones I, Jones L, Breen G, Farmer AE, McGuffin P, Vincent JB, Kennedy JL, Lewis CM · PubMed 33783297

  Suicide is a major public health problem and it has a prominent genetic component. We performed a genome-wide association study (GWAS) of suicidal behaviour severity. Suicide behaviour severity was assessed within the Schedules for Clinical Assessment in Neuropsychiatry in our mood disorder sample ( = 3506) for the GWAS. We also performed polygenic risk score analyses to explore genetic sharing between suicidal behaviour severity and a number of phenotypes, including bipolar disorder, major depressive disorder, alcoholism, post-traumatic stress disorder, impulsivity, insomnia, educational attainment, loneliness, maltreatment, and amygdala volume. We did not detect genome-wide significant findings at the single-marker or gene level. We report a number of suggestive single-marker and gene-

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