rs11071365 - ALDH1A2
Magnitude 2.2 · 1 study on file
Reported associations
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Translational genomics of osteoarthritis in 1,962,069 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 40205036
ABSTRACT: Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including transcriptome, proteome and epigenome profiles of primary joint tiss
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Hand osteoarthritis risk and prevention strategies Moderate
Genetic predisposition to hand osteoarthritis (1.1x risk per A allele) warrants clinical guidance on prevention approaches
Screening
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Hand osteoarthritis screening Moderate
ALDH1A2 rs11071365 A allele increases thumb and finger osteoarthritis risk 1.1x per allele in large genome-wide studies
Clinical hand and finger examination every 2-3 years starting at age 40