Expressive

rs11070816 - TRPM1

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment - Unknown journal (n.d.) · Unknown authors · PubMed 32080354

    ABSTRACT: Angioedema in the mouth or upper airways is a feared adverse reaction to angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) treatment, which is used for hypertension, heart failure and diabetes complications. This candidate gene and genome-wide association study aimed to identify genetic variants predisposing to angioedema induced by these drugs. The discovery cohort consisted of 173 cases and 4890 controls recruited in Sweden. In the candidate gene analysis, ETV6, BDKRB2, MME, and PRKCQ were nominally associated with angioedema (p < 0.05), but did not pass Bonferroni correction for multiple testing (p < 2.89 × 10−5). In the genome-wide analysis, intronic variants in the calcium-activated potassium channel subunit alpha-1 (KCNMA1)

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • ACE inhibitor and ARB sensitivity risk Moderate

    TRPM1 variant impairs ion channel function, increasing angioedema risk 1.79-fold when taking ACEi or ARB medications

    Inform physician of genetic finding before starting ACEi or ARB

Drug interactions

  • ACE inhibitors and angiotensin receptor blockers Moderate

    TRPM1 variant increases angioedema risk with ACEi/ARB by altering TRP channel-mediated vascular permeability regulation

    Choose alternative antihypertensive classes if available; discuss with physician

Screening

  • Angioedema symptoms if taking ACEi or ARB Moderate

    TRPM1 variant increases angioedema susceptibility when exposed to ACEi/ARB through altered ion channel signaling

    If on these medications, report facial, throat, tongue, or lip swelling immediately