rs11070264 - RPLP0P10 - INAFM2
Magnitude 4.5 · 1 study on file
Reported associations
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Genetic relationships between high blood eosinophil count, asthma susceptibility, and asthma severity. - The Journal of asthma : official journal of the Association for the Care of Asthma (2024) · Li H, Li X · PubMed 37560908
Genetic relationships between blood eosinophil count (BEC), asthma susceptibility, and severity are unclear. We sought to identify the genetic difference between type 2 (T2) and nontype 2 (non-T2) asthma (defined by BEC) and investigate genetic relationships between high BEC, asthma susceptibility, and severity. Genome-wide association studies (GWASs) were performed for T2 ( = 9,064; BEC ≥ 300 cells/μL) versus non-T2 asthma ( = 14,379; BEC < 150 cells/μL) and asthma susceptibility (37,227 asthmatics vs. 124,132 nonasthma controls) in the UK Biobank and asthma severity (moderate-to-severe asthma [ = 2,153] vs. mild asthma [ = 5165]) in the All of Us Research Program (AoURP). Genetic causality between BEC, asthma susceptibility, and severity were dissected using Mendelian randomi
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic risk for moderate-to-severe asthma Moderate
Variant associated with increased risk of moderate-to-severe asthma phenotype, suggesting potential benefit of earlier treatment intensification
Discuss with physician; have low threshold for step-up therapy
Screening
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Asthma severity progression assessment Moderate
C allele carriers show 1.95-fold increased odds of moderate-to-severe asthma, warranting vigilant monitoring for symptom progression
Annual spirometry and asthma control assessment if asthma present