rs1106952 - WNK2
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827
ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Systolic blood pressure monitoring Moderate
WNK2 variant associated with systolic blood pressure elevation; risk carriers show baseline elevation in large population studies
Establish baseline blood pressure reading; monitor at least annually or per physician recommendation