rs11065671 - PPTC7
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population - Unknown journal (n.d.) · Unknown authors · PubMed 40465716
ABSTRACT: We addressed the underrepresentation of non-European populations in genome-wide association studies (GWASs) by building HiGenome, a large-scale genetic resource for the Taiwanese Han population. Using a custom genotyping array, we integrated deidentified electronic medical records (2003 to 2021) with genomic data to enable GWASs, phenome-wide association studies, and polygenic risk score (PRS) analysis. Among 413,000 participants, 323,397 passed ancestry and quality control filtering. GWASs covered 1085 traits, focusing on diseases prevalent in Taiwan such as type 2 diabetes, chronic kidney disease, gout, and alcoholic liver damage. PRSs were calculated for 238 traits, with the strongest associations observed in musculoskeletal disorders. Incorporating PRS into clinical practice
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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excessive alcohol consumption Moderate
PPTC7 rs11065671 is associated with increased genetic susceptibility to alcohol-related liver damage
Limit to <=1 drink daily, or abstain if possible given genetic predisposition
Discuss with your doctor
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personalized alcohol safety and liver health Moderate
PPTC7 rs11065671 is associated with increased genetic susceptibility to alcohol-related liver damage
Discuss this genetic finding with your healthcare provider to establish safe alcohol limits and screening schedule
Screening
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liver function panel Moderate
PPTC7 rs11065671 is associated with increased genetic susceptibility to alcohol-related liver damage
Annual or biennial liver enzyme testing (ALT, AST, GGT, bilirubin)