Expressive

rs11065389 - HNF1A

Magnitude 2.2 · 1 study on file

Reported associations

  • Pleiotropic genetic architecture and novel loci for C-reactive protein levels - Unknown journal (n.d.) · Unknown authors · PubMed 36376304

    ABSTRACT: C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci, we perform multi-trait analysis of genome-wide association studies on C-reactive protein levels along with cardiometabolic traits, followed by a series of in silico analyses including colocalization, phenome-wide association studies and Mendelian randomization. We find 41 novel loci and 19 gene sets associated with C-reactive protein with various pleiotropic effects. Additionally, 41 variants colocalize between C-reactive protein and cardiometabolic risk factors and 12 of them display

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Anti-inflammatory dietary pattern Moderate

    Mediterranean-style diets rich in omega-3s, polyphenols, and fiber reduce CRP levels and cardiovascular risk

    Emphasize whole grains, fatty fish, leafy greens, legumes, olive oil; limit processed foods, refined carbs, red meat

Discuss with your doctor

  • Cardiovascular risk assessment Moderate

    This variant's effect on elevated CRP warrants proactive cardiovascular risk evaluation and management strategies

Exercise

  • Regular aerobic exercise Moderate

    Aerobic activity reduces CRP levels and improves cardiovascular health outcomes

    150 minutes moderate-intensity aerobic exercise per week (e.g. brisk walking, cycling, swimming)

Screening

  • C-reactive protein levels Moderate

    This variant increases baseline CRP, an inflammatory marker associated with cardiovascular and metabolic risk

    Baseline CRP measurement, then annually or per physician recommendation