rs1106346 - PARP15

Magnitude 2.2 · 1 study on file

Reported associations

• Host control of persistent Epstein-Barr virus infection - Unknown journal (n.d.) · Unknown authors · PubMed 41714741

  ABSTRACT: Epstein-Barr virus (EBV) infects approximately 90-95% of the global population and persists in B cells as a lifelong infection. Previous EBV infection is associated with autoimmune and neoplastic disease. Still, the biological basis of host control during EBV persistence remains unclear. Here we report the identification of non-genetic and genetic factors that are associated with EBV control during persistent infection. Using blood-based genome sequence data from 486,315 UK Biobank and 336,123 All of Us participants, we identified short-read pairs mapping to the EBV genome in 16.2% and 21.8% of individuals, respectively. EBV read detection (EBVread+) reflects increased viral load in blood cells, as shown by orthogonal measurements, and was associated with HIV infection, immu

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