Expressive

rs11062148 - CACNA1C

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-wide meta-analyses of cross substance use disorders in diverse populations - Unknown journal (n.d.) · Unknown authors · PubMed 41057643

    ABSTRACT: Substance use disorders (SUDs, including alcohol, cannabis, opioids, and tobacco) represent significant public health challenges. The estimated heritability of SUDs is ~50% and many individuals experience multiple SUDs concurrently. Studies have demonstrated the existence of genes shared across multiple SUDs, and identifying these SUD-shared genes is critical to developing novel prevention and treatment strategies. Here, we conducted the largest cross SUD meta-analysis to date to identify SUD-shared genes using samples genetically similar to 1000 Genomes Project European (1kg-EUR-like), African (1kg-AFR-like), and American mixed (1kg-AMR-like) populations. We defined variants that had the same direction of effects across different SUDs (i.e., concordant variants) as SUD-shared. I

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic predisposition to substance use disorder Moderate

    CACNA1C T allele at rs11062148 increases substance use disorder risk; provider counseling enables preventive intervention

    inform provider of genetic finding and discuss behavioral risk and prevention strategies

Lifestyle

  • recreational drug use and excessive alcohol High

    CACNA1C T allele increases substance use disorder susceptibility; substance avoidance is primary prevention

    complete abstinence from recreational drugs; minimize alcohol consumption

Screening

  • psychological screening for substance use vulnerability Moderate

    Early identification of substance use behaviors in genetically predisposed individuals enables timely preventive intervention

    discuss formal psychological screening and behavioral intervention program eligibility with healthcare provider