Expressive

rs1105797 - HMCN2

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic risk for inguinal hernia Moderate

    Genome-wide association study (n=275,546) identified rs1105797-A as risk allele for inguinal hernia (p=2.0e-9, OR 1.07)

    Inform healthcare provider of genetic risk to enable risk-stratified screening and counseling

    • GWAS_CATALOG:34382107

Lifestyle

  • heavy lifting and excessive straining Moderate

    Increased intra-abdominal pressure worsens hernia risk; HMCN2 variant affects extracellular matrix structure, compounding mechanical stress effects

    Avoid lifting over 50 lbs; manage constipation; use proper lifting technique; maintain healthy body weight

    • GWAS_CATALOG:34382107

Screening

  • inguinal hernia screening assessment Moderate

    HMCN2 structural protein variant rs1105797 increases inguinal hernia risk (OR 1.07); early detection enables timely intervention

    Discuss baseline screening approach with healthcare provider; monitor for groin pain, swelling, or bulging

    • GWAS_CATALOG:34382107