rs11057793 - NCOR2 - SCARB1

Magnitude 4.5 · 1 study on file

Reported associations

• Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function - Unknown journal (n.d.) · Unknown authors · PubMed 30061609

  ABSTRACT: Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newl

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