rs11056394 - RERG

Magnitude 2.0 · 1 study on file

Reported associations

• The genetic architecture of cervical length is shared with spontaneous preterm birth risk - Communications medicine (2025) · Wolf HM, Webb BT, Strauss JF, Tarca AL, Romero R, Hassan SS, Latendresse SJ, Chaiworapongsa T, Berry S, Gomez-Lopez N, Chaemsaithong P, York TP · PubMed 40813921

  ABSTRACT: Background Sonographic cervical length is a powerful predictor of maternal risk for spontaneous preterm birth (sPTB). Twin and family studies have established a maternal genetic heritability for sPTB ranging from 13 to 20%, however, there is no corresponding estimate for the heritability of mid-trimester cervical length, or an understanding of how genetic factors contribute to cervical changes across pregnancy. Methods This study was based on a prospective longitudinal cohort of (N = 5,160) Black/African American women who underwent serial sonographic examination of the uterine cervix during pregnancy and were genotyped via next-generation low-pass whole genome sequencing. Results Bivariate genetic correlations estimated using genome-wide complex trait analysis (GCTA) indicat

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