rs11054833 - MANSC1 - LOH12CR2
Magnitude 4.5 · 1 study on file
Reported associations
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Association of Genetic Variation at Locus with Vascular Depression. - Biomolecules (2019) · Westermair AL, Munz M, Schaich A, Nitsche S, Willenborg B, Muñoz Venegas LM, Willenborg C, Schunkert H, Schweiger U, Erdmann J · PubMed 30563176
Despite its substantial clinical importance, specific genetic variants associated with depression have not yet been identified. We sought to identify genetic variants associated with depression by (a) focusing on a more homogenous subsample (vascular depression) and (b) applying a three-stage approach. First, we contacted 730 participants with a confirmed atherosclerotic disease (coronary artery disease) from a population-based study population (German Myocardial Infarction Family Study IV) for psychiatric assessment with the Mini International Neuropsychiatric Interview. Second, we genotyped these patients using genome-wide single nucleotide polymorphism (SNP) arrays. Third, we characterized the SNP via in-silico analysis. The final sample consisted of 342 patients (78.3% male, age = 63.2
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Depression risk and genetic predisposition Moderate
This variant is associated with major depression risk in patients with coronary artery disease, suggesting increased vigilance for depressive symptoms
Discuss with your physician about depression screening options, especially if you develop cardiovascular symptoms
Screening
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Depressive symptoms and mood Moderate
This genetic variant increases major depression risk, warranting periodic monitoring for mood changes and depressive episodes