rs11054069 - PRR4, PRH1

Magnitude 2.2 · 1 study on file

Reported associations

• Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets - Unknown journal (n.d.) · Unknown authors · PubMed 37563310

  ABSTRACT: Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans). Integration of pQTL data with eQTL and disease genome-wide association studies provided insight into pathogenesis, implicating lymphotoxin-α in multiple sclerosis. Using Mendelian randomization (MR) to assess causality in disease etiology, we identified both shared and distinct effects of specific proteins across immune-mediated diseases, including directionally discordant effects of CD40 on risk of rheumatoid arthritis ve

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